Save your brain. Time Matters.

Lab tests can help detect problems early.

Blood-based biomarker testing is essential to early Alzheimer’s disease risk detection. When combined with memory and sleep testing, we can get a bird’s eye view of what is going on. It may give us time to slow, halt, or even reverse damage done. Blood tests such as beta-amyloid, phosphorylated tau, and apolipoprotein E can help guide prevention and treatment.

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Elevate your detection

Lab Testing

Lab testing provides an accurate way to assess your risk factors, in detail, without needing to visit a neurologist or primary care provider to get the orders.

Expert Analysis

Receive detailed reports analyzed by certified neurologists tailored to your specific needs.

Personal Support

Get ongoing support and recommendations from our dedicated team after your lab tests.

What are neurofibrillary tangles?

Amyloid-beta (Aβ) and phosphorylated tau (p-tau) serve as critical biomarkers and indicators for Alzheimer’s disease (AD).

Aβ is a peptide that originates from the amyloid-β precursor protein (APP), predominantly found in various tissues, particularly the brain. The accumulation of Aβ is recognized as a significant pathological feature of AD. P-tau, a microtubule-associated protein, plays a vital role in stabilizing microtubules within axons and dendrites. Under pathological conditions, tau undergoes hyperphosphorylation, resulting in its dysfunction, which contributes to synaptic impairment and neuronal degeneration.

In the context of AD, the buildup of Aβ and p-tau leads to synaptic abnormalities, exerting both direct and indirect cytotoxic effects that disrupt neurotransmission, creating neurofibrillary tangles, and contribute to inflammation, ultimately exacerbating the disease’s progression. Aβ and p-tau are tested at Brainology.

Are there genetic markers?

Apolipoprotein E (APOE) is a crucial protein involved in the transport of cholesterol and other lipids within the bloodstream, encoded by the APOE gene. It forms lipoproteins by binding with fats, facilitating the movement of cholesterol and other lipids throughout the circulatory system. Additionally, APOE plays a significant role in lipid transport and the repair of injuries in the brain.

The APOE gene has three primary alleles: APOE2, APOE3, and APOE4, with APOE3 being the most prevalent, present in over fifty percent of the population. The presence of the APOE4 allele is associated with an increased risk of late-onset Alzheimer’s disease, potentially contributing to approximately one-third of all cases. An APOE test can assess the specific APOE alleles present in an individual’s blood sample.